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Plants contain different types of bio-active compounds that can be used to cure many diseases and also they can cure against many infectious diseases. These compounds are known as phytochemicals they may be primary or secondary constituents. Primary constituents have proteins, sugar, amino acids. Secondary constituents contain terpenoids, flavonoids and alkaloids. These compounds have antifungal as well as antibacterial activities.In this study different plants that are commonly found in Dera Ismail Khan region was investigated for phytochemical analysis, These plants were Acacia Nilotica, Luffa Cylindrical, Morus Nigra, Morus Alba, Punica Granatum and Psidium Guava commonly available in Dera Ismail khan region of Pakistan. Leaves, flower and fruits were washed, dried in air and ground to powdered. Aqueous extracts of leaves, flower and fruits were used for phytochemical analysis. All the parts were rich in phytochemicals i.e. terpenoids, tannins, flavonoids and steroids, etc. The phytochemical analysis has a great interest in pharmaceutical industries for new drugs and for curing different diseases. These phytochemicals found in this study can be used for curing different diseases.