This paper examines the various applications of indigenous pesticidal plants into use to improve food security, medicine, livelihood, and agricultural production. A total of 350 crop farmers were purposively chosen were used to elicit information for this study. Data collected through questionnaires and oral discussion were analyzed descriptively. Results revealed availability of plenty indigenous pesticidal plants of great importance. These include neem leaf (80%), scent leaf (70%), garlic (60%), and ginger (55.7%). These plants contribute to food security through reduction of crop losses (82%), increase crop yield (78.6%), low cost of pest control (74.3%), and improved food quality (60%). As medicine, pesticidal plants are used for the treatment of malaria (80%), skin infections (75.7%), and anti-inflammatory agents (60%), stomach relief (71.4%) and among others. They improve livelihoods by reducing the cost of purchasing chemical pesticides (85.1%), increase crop yield (78.9%), reduced health risks (82%), and improves income (75.7%), among others. They reduce dependencies on synthetic pesticides (88.6%), reduce post-harvest losses (61.4%), and lower production costs (77.1%), among other. Despite the above pesticides, plants face the following adoption problem limited awareness (60%), time(55.7%), Poor storage (50%), lack of standardization (51.4%) and inconsistent efficacy (58.6%). Solving the problems include actions such as farmer education (88.6%), training on preparation (84.3%), community demonstration farms (65.7%), and research and documentation (70%), among others.