In the pursuit of alternative therapies for cognitive decline and memory enhancement, herbal remedies have gained significant attention. Among these, Salvia officinalis (sage) and Hypericum perforatum (St. John’s wort) have emerged as promising candidates due to their neuroprotective and cognitive-enhancing properties. This review explores the scientific evidence supporting the efficacy of a mixture of Salvia officinalis and Hypericum perforatum in improving memory and cognitive function and discuss the bioactive compounds present in these herbs, their mechanisms of action, and their individual effects on cognitive health. Furthermore, we examine preclinical and clinical studies investigating the synergistic effects of combining Salvia officinalis and Hypericum perforatum in mitigating cognitive decline and enhancing memory. Through a comprehensive analysis, this review aims to provide insights into the potential therapeutic benefits of this herbal mixture and its implications for cognitive health.