Genotype x environment interaction is a key factor in the selection of stable and high-performing accessions. The objective of this study is to determine the adaptability of high-performing sesame accessions in three locations in Côte d’Ivoire. Twenty-two sesame accessions were studied in Korhogo, Diawala, and Touba in 2022 and 2023, in a randomized complete block design with one factor (accessions) and four replicates. A combined AMMI (additive main effects and multiplicative interaction) analysis of variance was performed to evaluate the effect of genotypes, environments, and interaction. GGE-biplot (Genotype+ Genotype x Environment) methods were used to analyze the stability and performance of the accessions. The results showed that all the parameters studied were significantly influenced (P<0.001) by the environment, genotype, and their interaction. The genotype factor explained a small part of the variation compared to the environment and interaction. The latter indicated a differentiated response of the accessions depending on the environment. Analysis of the genotype-environment interaction revealed that accession A15 stood out for its stability and good performance in all environments, making it the best performer. Furthermore, the Diawala locality proved to be the most representative and discriminating, indicating that it is the most suitable area for sesame cultivation in the context of our study. The results obtained provide useful information for the development of future sesame improvement programs in Côte d'Ivoire. Accession A15 could thus be recommended to producers to improve sesame productivity and increase their incomes.