Caralluma procumbens is a member of genus Caralluma and family Apocynaceae. C. procumbens is a perennial succulent herb that is edible in different forms and widely used in traditional and folk medicine for the treatment of various diseases and also used significantly in nutraceuticals. Although C. procumbens is known to possess high economic value, it is under explored for its pharmacological and therapeutic potential. The objective of the study to evaluate and assess the medicinal importance of one of the underexplored tropical plant species C. procumbens. Determination of antioxidant activity in aqueous and methanolic extracts of C. procumbens was performed by adapting the 2,2-diphenyl-1-picrylhydrazyl scavenging assay. DNA damage inhibition ability was evaluated by UV irradiated photolysis of H2O2 in the presence of pET-28a plasmid with and without plant extracts. Aqueous and methanolic extracts of C. procumbens showed significant antioxidant activity as evidenced by DPPH radical scavenging activity. The IC50 values of aqueous and methanolic extracts were found to be 139.94 ug/ml and 86.91 ug/ml, respectively. Both the extracts significantly prevented the damage of pET-28a DNA. Our results suggest that C. Procumbens is endowed with high antioxidant potential and DNA damage inhibition ability. Hence this plant species could be a potential candidate for the development of phytochemical-based drugs and development of novel therapeutic strategies.