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Traditional medicine plays a vital role in healthcare delivery across Africa, where access to modern healthcare facilities may be limited. This review article provides a comprehensive ethnobotanical survey of medicinal plants used in traditional African medicine. Drawing upon a wide range of scholarly sources, ethnographic studies, and indigenous knowledge systems, the review explores the rich diversity of medicinal plants utilized by traditional healers and community members for the prevention and treatment of various ailments. The article examines the botanical diversity, therapeutic properties, preparation methods, and cultural significance of commonly used medicinal plants across different regions of Africa. Additionally, the review discusses the importance of preserving traditional knowledge, sustainable harvesting practices, and the integration of traditional medicine into modern healthcare systems. By documenting and promoting the use of medicinal plants in traditional African medicine, this review contributes to the conservation of biodiversity, preservation of cultural heritage, and enhancement of healthcare accessibility and affordability for diverse populations in Africa.